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KMID : 1134820000290020329
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 2 p.329 ~ p.334
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Saikosaponin Contents and cAMP Phosphodiesterase Inhibitory Activities in Bupleuri Radix Extracts According to Extraction Conditions
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Park In-Seon
Kang Eun-Mi
Park Young-Hyun
Kim Nam-Soo
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Abstract
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Two major oleananesaponins in Bupleuri radix, saikosaponin a and d, were extracted at various solvent compositions and leaching temperatures. Solvent composition was varied at 0 to 100%(v/v) of ethanol- water and methanol-water, whereas leaching temperature was adjusted to the range of 25～45℃. The most effective extractant and leaching temperature were 70% ethanol and 45℃, respectively. However, no major differences in saikosaponin content and cAMP phosphodiesterase inhibition were found at various leaching times. The cAMP phosphodiesterase inhibitions were also the highest when 70% ethanol was used as the extractant.
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KEYWORD
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saikosaponins, cyclicAMP phosphodiesterase, Bupleuri radix, extraction conditions
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